Sexually, that is? Have an (achievable) fantasy or something you've just always wondered about?
I have a few, but one is to answer one of those "casual encounters" ads on Craigslist and go get it on with a random guy for a night (without the drunken stupidity and regret of a bar hookup)... though it's a bit nerve-racking since I live in such a small community, I'm worried I'd end up at one of my student's or former student's houses. That'd be weird.
So what do you want to do?